The early nutritional environment of mice determines the capacity for adipose tissue expansion by modulating genes of caveolae structure.

ABSTRACT: While the phenomenon linking the early nutritional environment to disease susceptibility exists in many mammalian species, the underlying mechanisms are unknown. We hypothesized that nutritional programming is a variable quantitative state of gene expression, fixed by the state of energy balance in the neonate, that waxes and wanes in the adult animal in response to changes in energy balance. We tested this hypothesis with an experiment, based upon global gene expression, to identify networks of genes in which expression patterns in inguinal fat of mice have been altered by the nutritional environment during early post-natal development. The effects of over- and under-nutrition on adiposity and gene expression phenotypes were assessed at 5, 10, 21 days of age and in adult C57Bl/6J mice fed

SUBMITTER: Kozak LP 

PROVIDER: S-EPMC2888576 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature