The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized, double blind, cross-over study in thyroidectomized patients.

ABSTRACT:

Context

The substitution of liothyronine (L-T3) for levothyroxine (L-T4) is commonly employed during thyroid hormone (TH) withdrawal in preparation for diagnostic and therapeutic interventions on thyroid cancer patients. Presently, only limited data are available on the L-T3 for L-T4 therapeutic substitution. Objective To characterize the pharmcodynamic equivalence of L-T3 and L-T4.

Design

Randomized, double-blind, cross-over intervention study.

Setting

NIH clinical center.

Patients

Ten thyroidectomized patients.

Interventions

Study participants were treated with L-T3 or L-T4 with a target TSH >or= 0.5 Main out

SUBMITTER: Celi FS 

PROVIDER: S-EPMC2888764 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature