Synthesis and photophysical properties of sulfonamidophenyl porphyrins as models for activatable photosensitizers.

ABSTRACT: The ability to localize agents to specific anatomic sites remains an important aspect in designing more efficient therapeutics. Light-activated therapies, in particular, allow for the focal ablation of target tissues and cells. In order to increase the specificity of these agents, stimuli-activated systems have been developed, which are nonphototoxic in the absence of activation. To this end, we propose a novel paradigm for excited state quenching and activation based upon the direct conjugation of quenching moieties to the porphyrinic macrocycle. Model compounds, based upon meso-(p-aminophenyl)porphyrins were synthesized bearing 1 to 4 sulfonamide-linked 2,4-dinitrobenzene. The singlet oxygen and fluorescence quantum yields of these compounds were obtained and compared, as well as the kin

SUBMITTER: Bhaumik J 

PROVIDER: S-EPMC2888918 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature