Relationship of p53 overexpression on cancers and recognition by anti-p53 T cell receptor-transduced T cells.

ABSTRACT: Tumor suppressor p53 is reported to be an attractive immunotherapy target because it is mutated in approximately half of human cancers, resulting in inactivation and often an accumulation of the protein in the tumor cells. Only low amounts of protein are detectable in normal tissues. The differential display of antigen in normal versus tumor tissues has been reported to create an opportunity to target p53 by immunotherapy. We sought to determine the relationship between p53 expression and its recognition by cognate T cells in human tumors including common epithelial malignancies. Inasmuch as nonsense or missense p53 mutations may disrupt processing and presentation, we studied tumors with either identified wild-type or mutated p53, based on our gene-sequencing studies or published data. T

SUBMITTER: Theoret MR 

PROVIDER: S-EPMC2889139 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature