Andes virus infections in the rodent reservoir and in humans vary across contrasting landscapes in Chile.

ABSTRACT: Hantavirus cardiopulmonary syndrome (HCPS) is an emerging infectious disease first reported in Chile in 1995. Andes hantavirus (ANDV) is responsible for the more than 500 cases of HCPS reported in Chile. Previous work showed that ANDV is genetically differentiated in Chile across contrasting landscapes. To determine whether the reservoir rodent (Oligoryzomys longicaudatus) populations are also geographically segregated, we conducted range-wide spatial genetic analyses of O. longicaudatus in Chile using the mitochondrial DNA cytochrome b gene. Given that landscape structure influences the incidence of hantavirus infections, we also tested 772 O. longicaudatus specimens for antibodies to ANDV captured during the period 2000-2006. Population genetic analyses of O. longicaudatus are largely co

SUBMITTER: Torres-Perez F 

PROVIDER: S-EPMC2889182 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature