Perifornical Urocortin-3 mediates the link between stress-induced anxiety and energy homeostasis.

ABSTRACT: In response to physiological or psychological challenges, the brain activates behavioral and neuroendocrine systems linked to both metabolic and emotional outputs designed to adapt to the demand. However, dysregulation of integration of these physiological responses to challenge can have severe psychological and physiological consequences, and inappropriate regulation, disproportional intensity, or chronic or irreversible activation of the stress response is linked to the etiology and pathophysiology of mood and metabolic disorders. Using a transgenic mouse model and lentiviral approach, we demonstrate the involvement of the hypothalamic neuropeptide Urocortin-3, a specific ligand for the type-2 corticotropin-releasing factor receptor, in modulating septal and hypothalamic nuclei responsib

SUBMITTER: Kuperman Y 

PROVIDER: S-EPMC2889556 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature