A locus mapping to mouse chromosome 7 determines infarct volume in a mouse model of ischemic stroke.

ABSTRACT:

Background

In a mouse model of focal cerebral ischemia, infarct volume is highly variable and strain dependent, but the natural genetic determinants responsible for this difference remain unknown. To identify genetic determinants regulating ischemic neuronal damage and to dissect apart the role of individual genes and physiological mechanisms in infarction in mice, we performed quantitative trait locus analysis of surgically induced cerebral infarct volume.

Methods and results

After permanent occlusion of the distal middle cerebral artery, infarct volume was determined for 16 inbred strains of mice, chromosome substitution strains, and for 2 intercross cohorts, F2 (B6xBALB/c) and F2 (B6xSWR/J). Genome-wide linkage analysis was performed for infarct volume as a quantitative t

SUBMITTER: Keum S 

PROVIDER: S-EPMC2889618 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature