Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action.

ABSTRACT:

Objective

An increase in the rate of gluconeogenesis is largely responsible for the hyperglycemia in individuals with type 2 diabetes, with the antidiabetes action of metformin being thought to be achieved at least in part through suppression of gluconeogenesis.

Research design and methods

We investigated whether the transcription factor KLF15 has a role in the regulation of gluconeogenesis and whether KLF15 participates in the antidiabetes effect of metformin.

Results

Here we show that KLF15 regulates the expression of genes for gluconeogenic or amino acid-degrading enzymes in coordination with the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1alpha. Liver-specific ablation of KLF15 in diabetic mice resulted in downregulati

SUBMITTER: Takashima M 

PROVIDER: S-EPMC2889759 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature