Combined analyses of 20 common obesity susceptibility variants.

ABSTRACT:

Objective

Genome-wide association studies and linkage studies have identified 20 validated genetic variants associated with obesity and/or related phenotypes. The variants are common, and they individually exhibit small-to-modest effect sizes.

Research design and methods

In this study we investigate the combined effect of these variants and their ability to discriminate between normal weight and overweight/obese individuals. We applied receiver operating characteristics (ROC) curves, and estimated the area under the ROC curve (AUC) as a measure of the discriminatory ability. The analyses were performed cross-sectionally in the population-based Inter99 cohort where 1,725 normal weight, 1,519 overweight, and 681 obese individuals were successfully genotyped for all 20 variants

SUBMITTER: Sandholt CH 

PROVIDER: S-EPMC2889766 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature