Selected microRNAs define cell fate determination of murine central memory CD8 T cells.

ABSTRACT: During an immune response T cells enter memory fate determination, a program that divides them into two main populations: effector memory and central memory T cells. Since in many systems protection appears to be preferentially mediated by T cells of the central memory it is important to understand when and how fate determination takes place. To date, cell intrinsic molecular events that determine their differentiation remains unclear. MicroRNAs are a class of small, evolutionarily conserved RNA molecules that negatively regulate gene expression, causing translational repression and/or messenger RNA degradation. Here, using an in vitro system where activated CD8 T cells driven by IL-2 or IL-15 become either effector memory or central memory cells, we assessed the role of microRNAs in memor

SUBMITTER: Almanza G 

PROVIDER: S-EPMC2889817 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature