Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia.

ABSTRACT:

Context

Cannabis use is associated with both impaired cognitive functions, including working memory, and an increased risk of schizophrenia. Schizophrenia is characterized by impairments in working memory that are associated with reduced gamma-aminobutyric acid (GABA) neurotransmission in the dorsolateral prefrontal cortex. The cannabinoid 1 receptor (CB1R) is highly expressed in the dorsolateral prefrontal cortex, is contained in the axon terminals of a subpopulation of perisomatic-targeting GABA neurons, and, when activated, suppresses the release of GABA.

Objective

To determine the potential relationship between CB1R signaling and altered GABA neurotransmission in schizophrenia by evaluating CB1R messenger RNA (mRNA) and protein expression in the dorsolateral prefrontal c

SUBMITTER: Eggan SM 

PROVIDER: S-EPMC2890225 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature