Metabolomic and transcriptomic stress response of Escherichia coli.

ABSTRACT: Environmental fluctuations lead to a rapid adjustment of the physiology of Escherichia coli, necessitating changes on every level of the underlying cellular and molecular network. Thus far, the majority of global analyses of E. coli stress responses have been limited to just one level, gene expression. Here, we incorporate the metabolite composition together with gene expression data to provide a more comprehensive insight on system level stress adjustments by describing detailed time-resolved E. coli response to five different perturbations (cold, heat, oxidative stress, lactose diauxie, and stationary phase). The metabolite response is more specific as compared with the general response observed on the transcript level and is reflected by much higher specificity during the early stress a

SUBMITTER: Jozefczuk S 

PROVIDER: S-EPMC2890322 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature