An information-flow-based model with dissipation, saturation and direction for active pathway inference.

ABSTRACT:

Background

Biological systems process the genetic information and environmental signals through pathways. How to map the pathways systematically and efficiently from high-throughput genomic and proteomic data is a challenging open problem. Previous methods design different heuristics but do not describe explicitly the behaviours of the information flow.

Results

In this study, we propose new concepts of dissipation, saturation and direction to decipher the information flow behaviours in the pathways and thereby infer the biological pathways from a given source to its target. This model takes into account explicitly the common features of the information transmission and provides a general framework to model the biological pathways. It can incorporate different types of bio-mo

SUBMITTER: Ren X 

PROVIDER: S-EPMC2890502 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature