Candidate genes for chromosomes 6 and 10 quantitative trait loci for age-related retinal degeneration in mice.

ABSTRACT:

Purpose

In a previous study, several quantitative trait loci (QTL) that influence age-related degeneration (ageRD) were identified in a cross between the albino strains B6(Cg)-Tyr(c-2J)/J (B6a) and BALB/cByJ (C). The Chromosome (Chr) 6 and Chr 10 QTL were the strongest and most highly significant loci and both involved B6a protective alleles. The QTL were responsible for 21% and 9% of the variance in phenotypes, respectively. We focused on these two QTL to identify candidate genes.

Methods

DNA microarrays were used for the two mouse strains at four and eight months of age to identify genes that are differentially regulated and map to either QTL. Gene Ontology (GO) analysis of the differentially expressed genes was performed to identify possible processes and pathways associa

SUBMITTER: Ogando DG 

PROVIDER: S-EPMC2890552 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature