Inferring linkage disequilibrium from non-random samples.

ABSTRACT:

Background

Linkage disequilibrium (LD) plays a fundamental role in population genetics and in the current surge of studies to screen for subtle genetic variants affecting complex traits. Methods widely implemented in LD analyses require samples to be randomly collected, which, however, are usually ignored and thus raise the general question to the LD community of how the non-random sampling affects statistical inference of genetic association. Here we propose a new approach for inferring LD using a sample un-randomly collected from the population of interest.

Results

Simulation study was conducted to mimic generation of samples with various degrees of non-randomness from the simulated populations of interest. The method developed in the paper outperformed its rivals in adequ

SUBMITTER: Wang M 

PROVIDER: S-EPMC2890561 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature