HOXB13 promotes androgen independent growth of LNCaP prostate cancer cells by the activation of E2F signaling.

ABSTRACT:

Background

Androgen signaling plays a critical role in the development of prostate cancer and its progression. However, androgen-independent prostate cancer cells emerge after hormone ablation therapy, resulting in significant clinical problems. We have previously demonstrated that the HOXB13 homeodomain protein functions as a prostate cancer cell growth suppressor by inhibiting androgen-mediated signals. However, the role of the HOXB13 in androgen-independent growth of prostate cancer cells remains unexplained.

Results

In this report, we first demonstrated that HOXB13 was highly overexpressed in hormone-refractory tumors compared to tumors without prostate-specific antigen after initial treatment. Functionally, in an androgen-free environment minimal induction of HOXB13 in

SUBMITTER: Kim YR 

PROVIDER: S-EPMC2890607 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature