Protein interface conservation across structure space.

ABSTRACT: With the advent of Systems Biology, the prediction of whether two proteins form a complex has become a problem of increased importance. A variety of experimental techniques have been applied to the problem, but three-dimensional structural information has not been widely exploited. Here we explore the range of applicability of such information by analyzing the extent to which the location of binding sites on protein surfaces is conserved among structural neighbors. We find, as expected, that interface conservation is most significant among proteins that have a clear evolutionary relationship, but that there is a significant level of conservation even among remote structural neighbors. This finding is consistent with recent evidence that information available from structural neighbors, inde

SUBMITTER: Zhang QC 

PROVIDER: S-EPMC2890749 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature