Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo.

ABSTRACT: A unique property of the mammalian embryo is that stem cells can be derived from its early tissue lineages. These lineages will give rise to the fetus as well as essential extraembryonic tissues. Understanding how chromatin regulation participates in establishment of these lineages in the embryo and their derived stem cells provides insight that will critically inform our understanding of embryogenesis and stem cell biology. Here, we compare the genomewide location of active and repressive histone modifications in embryonic stem cells, trophoblast stem cells, and extraembryonic endoderm stem cells from the mouse. Our results show that the active modification H3K4me3 has a similar role in the three stem cell types, but the repressive modification H3K27me3 varies in abundance and genomewide

SUBMITTER: Rugg-Gunn PJ 

PROVIDER: S-EPMC2890770 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature