Vitamin D receptor gene polymorphisms and hepatocellular carcinoma in alcoholic cirrhosis.

ABSTRACT:

Aim

To assess the relationship between vitamin D receptor (VDR) gene polymorphisms and the presence of hepatocellular carcinoma (HCC).

Methods

Two-hundred forty patients who underwent liver transplantation were studied. The etiologies of liver disease were hepatitis C (100 patients), hepatitis B (37) and alcoholic liver disease (103). A group of 236 healthy subjects served as controls. HCC in the explanted liver was detected in 80 patients. The following single nucleotide gene polymorphisms of the VDR were investigated by polymerase chain reaction and restriction fragment length polymorphism: FokI C>T (F/f), BsmI A>G (B/b), ApaI T>G (A/a) and TaqI T>C (T/t) (BAT).

Results

The frequencies of genotypes in patients without and with HCC were for FokI F/F = 69, F/f = 73, f

SUBMITTER: Falleti E 

PROVIDER: S-EPMC2890942 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature