Transcriptional profiling of Clostridium difficile and Caco-2 cells during infection.

ABSTRACT: Clostridium difficile is well recognized as the most common infectious cause of nosocomial diarrhea. The incidence and severity of C. difficile infection (CDI) is increasing worldwide. Here, we evaluated simultaneously the transcriptional changes in the human colorectal epithelial Caco-2 cells and in C. difficile after infection. A total of 271 transcripts in Caco-2 cells and 207 transcripts in C. difficile were significantly differentially expressed at 1 time point during CDI. We used the gene ontology annotations and protein-protein network interactions to underline a framework of target molecules that could potentially play a key role during CDI. These genes included those associated with cellular metabolism, transcription, transport, cell communication, and signal transduction. Our dat

SUBMITTER: Janvilisri T 

PROVIDER: S-EPMC2891111 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature