The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease.

ABSTRACT:

Background & aims

Although nonalcoholic fatty liver disease (NAFLD) is increasingly common, only a minority of affected individuals develop fibrotic liver disease. Based on its role in liver growth and repair, we explored whether Kruppel-like factor 6 (KLF6) plays a role in NAFLD progression.

Methods

KLF6 expression in 31 fibrosis scored NAFLD liver biopsy specimens was assessed by real-time polymerase chain reaction. Transfected minigene constructs were used to study the effect of a polymorphism, KLF6-IVS1-27G>A, that promotes KLF6 alternative splicing in vitro. We genotyped KLF6-IVS1-27G>A in 3 groups of patients (UK group 1, n = 306; Italian group 2, n = 109; trio group 3, n = 61 children and parents).

Results

KLF6 expression was increased in association with incre

SUBMITTER: Miele L 

PROVIDER: S-EPMC2891245 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature