Effects of TNF-alpha antagonism on E-selectin in obese subjects with metabolic dysregulation.

ABSTRACT:

Objective

Endothelial adhesion molecules like E-selectin play an important role in leukocyte recruitment and development of atherosclerotic plaque. E-selectin is increased in obesity, yet little is known regarding the specific factors contributing to elevated E-selectin in obesity and whether tumour necrosis factor alpha (TNF-alpha) increases E-selectin in vivo in this population. The objectives of this study were to: (1) determine the body composition, metabolic and inflammatory factors associated with increased E-selectin and (2) determine the role of TNF-alpha in the physiological regulation of E-selectin by antagonism of TNF-alpha with etanercept among obese subjects.

Methods

E-selectin levels, body composition, metabolic parameters and inflammatory cytokines were assess

SUBMITTER: Zanni MV 

PROVIDER: S-EPMC2891313 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature