Familial chronic lymphocytic leukemia.

ABSTRACT:

Purpose of review

Families with multiple individuals affected with chronic lymphocytic leukemia (CLL) and other related B-cell tumors have been described in the literature and strong familial aggregation has been seen in population studies. However, predisposing germline mutations have not been identified. We will discuss the spectrum of conditions associated with CLL in families and the advances in identifying the underlying susceptibility genes.

Recent findings

Familial CLL does not appear to differ substantially from sporadic CLL in terms of prognostic markers and clinical outcome, although it may be associated with more indolent disease. The precursor condition, monoclonal B-cell lymphocytosis, also aggregates in CLL families. Linkage studies have been conducted in high-

SUBMITTER: Goldin LR 

PROVIDER: S-EPMC2891437 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature