Chronic cigarette smoke exposure generates pathogenic T cells capable of driving COPD-like disease in Rag2-/- mice.

ABSTRACT:

Rationale

Pathogenic T cells drive, or sustain, a number of inflammatory diseases. Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease associated with the accumulation of activated T cells. We previously demonstrated that chronic cigarette smoke (CS) exposure causes oligoclonal expansion of lung CD4(+) T cells and CD8(+) T cells in a mouse model of COPD, thus implicating these cells in disease pathogenesis.

Objectives

To determine whether T cells are pathogenic in a CS-induced mouse model of COPD.

Methods

We transferred lung CD3(+) T cells from filtered air (FA)- and CS-exposed mice into Rag2(-/-) recipients. Endpoints associated with the COPD phenotype were then measured.

Measurements and main results

Here, we demonstrate that chronic

SUBMITTER: Motz GT 

PROVIDER: S-EPMC2891493 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature