Prominent hippocampal CA3 gene expression profile in neurocognitive aging.

ABSTRACT: Research in aging laboratory animals has characterized physiological and cellular alterations in medial temporal lobe structures, particularly the hippocampus, that are central to age-related memory deficits. The current study compares molecular alterations across hippocampal subregions in a rat model that closely mirrors individual differences in neurocognitive features of aging humans, including both impaired memory and preserved function. Using mRNA profiling of the CA1, CA3 and dentate gyrus subregions, we have distinguished between genes and pathways related to chronological age and those associated with impaired or preserved cognitive outcomes in healthy aged Long-Evans rats. The CA3 profile exhibited the most prominent gene expression differences related to cognitive status and of t

SUBMITTER: Haberman RP 

PROVIDER: S-EPMC2891610 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature