Methylthioadenosine (MTA) inhibits melanoma cell proliferation and in vivo tumor growth.

ABSTRACT:

Background

Melanoma is the most deadly form of skin cancer without effective treatment. Methylthioadenosine (MTA) is a naturally occurring nucleoside with differential effects on normal and transformed cells. MTA has been widely demonstrated to promote anti-proliferative and pro-apoptotic responses in different cell types. In this study we have assessed the therapeutic potential of MTA in melanoma treatment.

Methods

To investigate the therapeutic potential of MTA we performed in vitro proliferation and viability assays using six different mouse and human melanoma cell lines wild type for RAS and BRAF or harboring different mutations in RAS pathway. We also have tested its therapeutic capabilities in vivo in a xenograft mouse melanoma model and using variety of molecular tech

SUBMITTER: Andreu-Perez P 

PROVIDER: S-EPMC2891639 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature