Maturation of the hippocampal formation and amygdala in Macaca mulatta: a volumetric magnetic resonance imaging study.

ABSTRACT: Malformations of the hippocampal formation and amygdala have been implicated in several neurodevelopmental disorders; yet relatively little is known about their normal structural development. The purpose of this study was to characterize the early developmental trajectories of the hippocampus and amygdala in the rhesus macaques (Macaca mulatta) using noninvasive MRI techniques. T1-weighted structural scans of 22 infant and juvenile monkeys (11 male, 11 female) were obtained between 1 week and approximately 2 yrs of age. Ten animals (five males, five females) were scanned multiple times and 12 monkeys (six males, six females) were scanned once between 1 and 4 weeks of age. Both structures exhibited significant age-related changes throughout the first 2 yrs of life that were not explained by

SUBMITTER: Payne C 

PROVIDER: S-EPMC2891665 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature