Congenital diaphragmatic hernia and associated cardiovascular malformations: type, frequency, and impact on management.

ABSTRACT: The co-occurrence of congenital diaphragmatic hernia (CDH) and cardiovascular malformations (CVMs) has important clinical, genetic, and developmental implications. Previous examinations of this topic often included patients with genetic syndromes. To correct this potential bias, we undertook an extensive review of the literature and obtained new data. The frequency of CVMs associated with isolated CDH was 11-15%. A careful analysis of CVMs indicates that atrial and ventricular septal defects, conotruncal defects, and left ventricular outflow tract obstructive defects were the most common type of CVMs, but proportional to the frequency of occurrence in the general population. The combination of CVM and CDH results in a poorer prognosis than would be expected with either malformation alone.

SUBMITTER: Lin AE 

PROVIDER: S-EPMC2891735 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature