A dynamic model of neurovascular coupling: implications for blood vessel dilation and constriction.

ABSTRACT: Neurovascular coupling in response to stimulation of the rat barrel cortex was investigated using concurrent multichannel electrophysiology and laser Doppler flowmetry. The data were used to build a linear dynamic model relating neural activity to blood flow. Local field potential time series were subject to current source density analysis, and the time series of a layer IV sink of the barrel cortex was used as the input to the model. The model output was the time series of the changes in regional cerebral blood flow (CBF). We show that this model can provide excellent fit of the CBF responses for stimulus durations of up to 16 s. The structure of the model consisted of two coupled components representing vascular dilation and constriction. The complex temporal characteristics of the CBF t

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC2891822 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature