Temporal lobe functional activity and connectivity in young adult APOE varepsilon4 carriers.

ABSTRACT:

Background

We sought to determine if the APOE epsilon4 allele influences both the functional activation and connectivity of the medial temporal lobes (MTLs) during successful memory encoding in young adults.

Methods

Twenty-four healthy young adults, i.e., 12 carriers and 12 noncarriers of the APOE epsilon4 allele, were scanned in a subsequent-memory paradigm, using event-related functional magnetic resonance imaging. The neuroanatomic correlates of successful encoding were measured as greater neural activity for subsequently remembered versus forgotten task items, or in short, encoding success activity (ESA). Group differences in ESA within the MTLs, as well as whole-brain functional connectivity with the MTLs, were assessed.

Results

In the absence of demographic or p

SUBMITTER: Dennis NA 

PROVIDER: S-EPMC2891943 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature