Target ranges of oxygen saturation in extremely preterm infants.

ABSTRACT:

Background

Previous studies have suggested that the incidence of retinopathy is lower in preterm infants with exposure to reduced levels of oxygenation than in those exposed to higher levels of oxygenation. However, it is unclear what range of oxygen saturation is appropriate to minimize retinopathy without increasing adverse outcomes.

Methods

We performed a randomized trial with a 2-by-2 factorial design to compare target ranges of oxygen saturation of 85 to 89% or 91 to 95% among 1316 infants who were born between 24 weeks 0 days and 27 weeks 6 days of gestation. The primary outcome was a composite of severe retinopathy of prematurity (defined as the presence of threshold retinopathy, the need for surgical ophthalmologic intervention, or the use of bevacizumab), death befo

SUBMITTER: SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research Network 

PROVIDER: S-EPMC2891970 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature