In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases.

ABSTRACT:

Background

CHI3L1 (YKL-40) is up-regulated in a variety of inflammatory conditions and cancers. We have previously reported elevated CHI3L1 concentration in the cerebrospinal fluid (CSF) of human and non-human primates with lentiviral encephalitis and using immunohistochemistry showed that CHI3L1 was associated with astrocytes.

Methods

In the current study CHI3L1 transcription and expression were evaluated in a variety of acute and chronic human neurological diseases.

Results

ELISA revealed significant elevation of CHI3L1 in the CSF of multiple sclerosis (MS) patients as well as mild elevation with aging. In situ hybridization (ISH) showed CHI3L1 transcription mostly associated with reactive astrocytes, that was more pronounced in inflammatory conditions like lentivir

SUBMITTER: Bonneh-Barkay D 

PROVIDER: S-EPMC2892443 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature