Hybrid modeling of biological networks: mixing temporal and qualitative biological properties.

ABSTRACT:

Background

Modeling a dynamical biological system is often a difficult task since the a priori unknown parameters of such models are not always directly given by the experiments. Despite the lack of experimental quantitative knowledge, one can see a dynamical biological system as (i) the combined evolution tendencies (increase or decrease) of the biological compound concentrations, and: (ii) the temporal features, such as delays between two concentration peaks (i.e. the times when one of the components completes an increase (resp. decrease) phase and starts a decrease (resp. increase) phase).

Results

We propose herein a new hybrid modeling framework that follows such biological assumptions. This hybrid approach deals with both a qualitative structure of the system and a quan

SUBMITTER: Fromentin J 

PROVIDER: S-EPMC2892461 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature