The gene expression profile in the synovium as a predictor of the clinical response to infliximab treatment in rheumatoid arthritis.

ABSTRACT:

Background

Although the use of TNF inhibitors has fundamentally changed the way rheumatoid arthritis (RA) is treated, not all patients respond well. It is desirable to facilitate the identification of responding and non-responding patients prior to treatment, not only to avoid unnecessary treatment but also for financial reasons. In this work we have investigated the transcriptional profile of synovial tissue sampled from RA patients before anti-TNF treatment with the aim to identify biomarkers predictive of response.

Methodology/principal findings

Synovial tissue samples were obtained by arthroscopy from 62 RA patients before the initiation of infliximab treatment. RNA was extracted and gene expression profiling was performed using an in-house spotted long oligonucleotide a

SUBMITTER: Lindberg J 

PROVIDER: S-EPMC2892481 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature