Systemic levels of G-CSF and interleukin-6 determine the angiogenic potential of bone marrow resident monocytes.

ABSTRACT: There is considerable interest in the potential of cell-based approaches to mediate therapeutic angiogenesis for acute and chronic vascular syndromes. Using a mouse model of HLI, we showed previously that adoptive transfer of a small number of donor monocytes enhanced revascularization significantly. Herein, we provide data suggesting that the BM resident monocytes sense systemic signals that influence their future functional capacity. Specifically, following induction of distant ischemia, the angiogenic capacity of BM resident monocytes is reduced markedly. We provide evidence that G-CSF and IL-6 represent such "conditioning" signals. Systemic levels of G-CSF and IL-6 are increased significantly following induction of HLI. Accordingly, BM resident monocytes from ischemic mice exhibited in

SUBMITTER: Gregory AD 

PROVIDER: S-EPMC2892524 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature