Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.

ABSTRACT: Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown. In contrast to many other common diseases for which genetic association-studies have successfully revealed common variants associated with disease risk, the role of common variation in partial epilepsies has not yet been explored in a well-powered study. We undertook a genome-wide association-study to identify common variants which influence risk for epilepsy shared amongst partial epilepsy syndromes, in 3445 patients and 6935 controls of European ancestry. We did not identify any genome-wide significant association. A few single nucleotide polymorphisms may warrant further investigation. We exclude common genetic variants with effect sizes above a modest 1.3 odds ratio for a single

SUBMITTER: Kasperaviciute D 

PROVIDER: S-EPMC2892941 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature