Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans.

ABSTRACT:

Background

Alcohol dependence is a major cause of morbidity and mortality worldwide and has a strong familial component. Several linkage and association studies have identified chromosomal regions and/or genes that affect alcohol consumption, notably in genes involved in the 2-stage pathway of alcohol metabolism.

Methods

Here, we use multiple regression models to test for associations and interactions between 2 alcohol-related phenotypes and SNPs in 17 genes involved in alcohol metabolism in a sample of 1,588 European American subjects.

Results

The strongest evidence for association after correcting for multiple testing was between rs1229984, a nonsynonymous coding SNP in ADH1B, and DSM-IV symptom count (p = 0.0003). This SNP was also associated with maximum number of

SUBMITTER: Sherva R 

PROVIDER: S-EPMC2892966 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature