Clinical and genetic factors associated with lipoprotein-associated phospholipase A2 in the Framingham Heart Study.

ABSTRACT:

Objective

To conduct an investigation of clinical and genetic correlates of lipoprotein-associated phospholipase (Lp-PLA(2)) activity and mass in a large community-based cohort. Higher circulating Lp-PLA(2) predicts cardiovascular disease risk, but sources of inter-individual variability are incompletely understood.

Methods

We conducted stepwise regression of clinical correlates of Lp-PLA(2) in four Framingham Heart Study cohorts (n=8185; mean age 50+/-14 years, 53.8% women, 9.8% ethnic/racial minority cohort). We also conducted heritability and linkage analyses in Offspring and Generation 3 cohorts (n=6945). In Offspring cohort participants we performed association analyses (n=1535 unrelated) with 1943 common tagging SNPs in 233 inflammatory candidate genes.

Results

SUBMITTER: Schnabel R 

PROVIDER: S-EPMC2893025 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature