Impaired embryonic development in mice overexpressing the RNA-binding protein TIAR.

ABSTRACT:

Background

TIA-1-related (TIAR) protein is a shuttling RNA-binding protein involved in several steps of RNA metabolism. While in the nucleus TIAR participates to alternative splicing events, in the cytoplasm TIAR acts as a translational repressor on specific transcripts such as those containing AU-Rich Elements (AREs). Due to its ability to assemble abortive pre-initiation complexes coalescing into cytoplasmic granules called stress granules, TIAR is also involved in the general translational arrest observed in cells exposed to environmental stress. However, the in vivo role of this protein has not been studied so far mainly due to severe embryonic lethality upon tiar invalidation.

Methodology/principal findings

To examine potential TIAR tissue-specificity in various cellula

SUBMITTER: Kharraz Y 

PROVIDER: S-EPMC2893167 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature