Obstructive sleep apnea alters sleep stage transition dynamics.

ABSTRACT:

Introduction

Enhanced characterization of sleep architecture, compared with routine polysomnographic metrics such as stage percentages and sleep efficiency, may improve the predictive phenotyping of fragmented sleep. One approach involves using stage transition analysis to characterize sleep continuity.

Methods and principal findings

We analyzed hypnograms from Sleep Heart Health Study (SHHS) participants using the following stage designations: wake after sleep onset (WASO), non-rapid eye movement (NREM) sleep, and REM sleep. We show that individual patient hypnograms contain insufficient number of bouts to adequately describe the transition kinetics, necessitating pooling of data. We compared a control group of individuals free of medications, obstructive sleep apnea (OSA),

SUBMITTER: Bianchi MT 

PROVIDER: S-EPMC2893208 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature