Fine mapping of the association with obesity at the FTO locus in African-derived populations.

ABSTRACT: Genome-wide association studies have identified many common genetic variants that are associated with polygenic traits, and have typically been performed with individuals of recent European ancestry. In these populations, many common variants are tightly correlated, with the perfect or near-perfect proxies for the functional or true variant showing equivalent evidence of association, considerably limiting the resolution of fine mapping. Populations with recent African ancestry often have less extensive and/or different patterns of linkage disequilibrium (LD), and have been proposed to be useful in fine-mapping studies. Here, we strongly replicate and fine map in populations of predominantly African ancestry the association between variation at the FTO locus and body mass index (BMI) that i

SUBMITTER: Hassanein MT 

PROVIDER: S-EPMC2893809 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature