Brain-derived neurotrophic factor regulates satellite cell differentiation and skeltal muscle regeneration.

ABSTRACT: In adult skeletal muscle, brain-derived neurotrophic factor (BDNF) is expressed in myogenic progenitors known as satellite cells. To functionally address the role of BDNF in muscle satellite cells and regeneration in vivo, we generated a mouse in which BDNF is specifically depleted from skeletal muscle cells. For comparative purposes, and to determine the specific role of muscle-derived BDNF, we also examined muscles of the complete BDNF(-/-) mouse. In both models, expression of the satellite cell marker Pax7 was significantly decreased. Furthermore, proliferation and differentiation of primary myoblasts was abnormal, exhibiting delayed induction of several markers of differentiation as well as decreased myotube size. Treatment with exogenous BDNF protein was sufficient to rescue normal ge

SUBMITTER: Clow C 

PROVIDER: S-EPMC2893983 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature