Differential expression of tissue repair genes in the pathogenesis of chronic obstructive pulmonary disease.

ABSTRACT:

Rationale

The airflow limitation that defines severity of chronic obstructive pulmonary disease (COPD) is caused by a combination of small airway obstruction and emphysematous lung destruction.

Objectives

To examine the hypothesis that small airway obstructive and emphysematous destructive lesions are produced by differential expression of genes associated with tissue repair.

Methods

The expression of 54 genes associated with repair of repetitively damaged tissue was measured in 136 paired samples of small bronchioles and surrounding lung tissue separated by laser capture microdissection. These samples were collected from 63 patients at different levels of disease severity who required surgery for either lung cancer or lung transplantation for very severe COPD. Gene e

SUBMITTER: Gosselink JV 

PROVIDER: S-EPMC2894408 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature