The role of surfactant protein A in bleomycin-induced acute lung injury.

ABSTRACT:

Rationale

Surfactant protein A (SP-A) is a collectin family member that has multiple immunomodulatory roles in lung host defense. SP-A levels are altered in the bronchoalveolar lavage (BAL) fluid and serum of patients with acute lung injury and acute respiratory distress syndrome, suggesting the importance of SP-A in the pathogenesis of acute lung injury.

Objectives

Investigate the role of SP-A in the murine model of noninfectious lung injury induced by bleomycin treatment.

Methods

Wild-type (WT) or SP-A deficient (SP-A(-/-)) mice were challenged with bleomycin, and various indices of lung injury were analyzed.

Measurements and main results

On challenge with bleomycin, SP-A(-/-) mice had a decreased survival rate as compared with WT mice. SP-A(-/-) mice had a h

SUBMITTER: Goto H 

PROVIDER: S-EPMC2894409 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature