Cytomegalovirus pneumonitis is a risk for bronchiolitis obliterans syndrome in lung transplantation.

ABSTRACT:

Rationale

Cytomegalovirus pneumonitis is one of the most prevalent opportunistic infections after lung transplantation. Early studies reported that cytomegalovirus pneumonitis was a risk factor for chronic allograft dysfunction. More recently, in the era of routine prophylaxis and ganciclovir treatment, the adverse impact of treated cytomegalovirus pneumonitis on bronchiolitis obliterans syndrome has been challenged.

Objectives

We hypothesized that cytomegalovirus pneumonitis contributes to adverse outcomes in the current antiviral era. We sought to define the impact of treated cytomegalovirus pneumonitis on bronchiolitis obliterans syndrome and survival in a large single-center cohort (n = 231) of consecutive patients undergoing lung transplantation from 2000 to 2004, all r

SUBMITTER: Snyder LD 

PROVIDER: S-EPMC2894412 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature