Toll-like receptor polymorphisms and age-related macular degeneration: replication in three case-control samples.

ABSTRACT:

Purpose

Innate immunity appears to play a key role in age-related macular degeneration (AMD). Although two previous studies reported that gene variations in Toll-like receptor (TLR)-3 and -4 are associated with AMD, other studies have not confirmed these associations. In this study, three independent samples (two U.S. clinic-based case-control study samples and one Australian population-based study sample) were used to further assess the association of the polymorphisms rs3775291 in TLR3 and rs4986790 in TLR4 with AMD.

Methods

AMD cases and unrelated controls were collected from the National Eye Institute Clinical Center (NEI, n = 320), the Age-Related Eye Disease Study (AREDS, n = 483), and the Blue Mountains Eye Study (BMES, n = 852). DNA extracted from subjects was genoty

SUBMITTER: Cho Y 

PROVIDER: S-EPMC2894575 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature