No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes.

ABSTRACT:

Background

The nuclear receptor NR4A1 is implicated in metabolic regulation in insulin-sensitive tissues, such as liver, adipose tissue, and skeletal muscle. Functional loss of NR4A1 results in insulin resistance and enhanced intramuscular and hepatic lipid content. Therefore, we investigated in a cohort of white European subjects at increased risk for type 2 diabetes whether genetic variation within the NR4A1 gene locus contributes to prediabetic phenotypes, such as insulin resistance, ectopic fat distribution, or beta-cell dysfunction.

Methods

We genotyped 1495 subjects (989 women, 506 men) for five single nucleotide polymorphisms (SNPs) tagging 100% of common variants (MAF = 0.05) within the NR4A1 gene locus with an r2 = 0.8. All subjects underwent an oral glucose toleran

SUBMITTER: Mussig K 

PROVIDER: S-EPMC2894787 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature