A gene network switch enhances the oxidative capacity of ovine skeletal muscle during late fetal development.

ABSTRACT:

Background

The developmental transition between the late fetus and a newborn animal is associated with profound changes in skeletal muscle function as it adapts to the new physiological demands of locomotion and postural support against gravity. The mechanisms underpinning this adaption process are unclear but are likely to be initiated by changes in hormone levels. We tested the hypothesis that this developmental transition is associated with large coordinated changes in the transcription of skeletal muscle genes.

Results

Using an ovine model, transcriptional profiling was performed on Longissimus dorsi skeletal muscle taken at three fetal developmental time points (80, 100 and 120 d of fetal development) and two postnatal time points, one approximately 3 days postpartum an

SUBMITTER: Byrne K 

PROVIDER: S-EPMC2894804 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature