Detecting internally symmetric protein structures.

ABSTRACT:

Background

Many functional proteins have a symmetric structure. Most of these are multimeric complexes, which are made of non-symmetric monomers arranged in a symmetric manner. However, there are also a large number of proteins that have a symmetric structure in the monomeric state. These internally symmetric proteins are interesting objects from the point of view of their folding, function, and evolution. Most algorithms that detect the internally symmetric proteins depend on finding repeating units of similar structure and do not use the symmetry information.

Results

We describe a new method, called SymD, for detecting symmetric protein structures. The SymD procedure works by comparing the structure to its own copy after the copy is circularly permuted by all possible numb

SUBMITTER: Kim C 

PROVIDER: S-EPMC2894822 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature