Duplicability of self-interacting human genes.

ABSTRACT:

Background

There is increasing interest in the evolution of protein-protein interactions because this should ultimately be informative of the patterns of evolution of new protein functions within the cell. One model proposes that the evolution of new protein-protein interactions and protein complexes proceeds through the duplication of self-interacting genes. This model is supported by data from yeast. We examined the relationship between gene duplication and self-interaction in the human genome.

Results

We investigated the patterns of self-interaction and duplication among 34808 interactions encoded by 8881 human genes, and show that self-interacting proteins are encoded by genes with higher duplicability than genes whose proteins lack this type of interaction. We show that

SUBMITTER: Perez-Bercoff A 

PROVIDER: S-EPMC2894830 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature